New research indicates that individuals who stop using popular weight-loss injections like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end conventional diet and exercise plans.
Published data in a leading health publication shows that while obese people often shed a large proportion of their total mass while using the jabs, the weight comes back at an average rate of 0.8 kg per month once they quit.
"Users buying such treatments must be cognizant of the risk of quick rebound weight gain when the therapy is stopped," cautioned expert Dr. Susan Jebb.
Such speed of regain means a return to starting weight within about a year and a half.
Weighing Approaches
The research, which looked at 37 of trials involving over 9,000 of participants, contrasted the effects of these new drugs with older methods.
Scientists point out that individuals who lose weight through dieting usually have a less rapid weight regain—approximately 100 grams monthly—post-intervention.
Understanding the Rapid Regain
Doctors propose the mode of action of the drugs explains the accelerated regain.
The injections copy a natural hormone called GLP-1, which moderates hunger.
"Artificially providing GLP-1 concentrations far above than the body's typical production might result in the system to produce less of its endogenous hormone, and may also diminish responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Stopping of this hormone supplement results in hunger is unsuppressed, making overeating far more likely."
A Chronic Issue?
Health authorities suggest the injections for people with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
Many experts argue that, given the high risk of weight regain, the therapy should be considered long-term.
This view is supported by pharmaceutical companies, who state that the findings "underscore the long-term nature of excess weight," similar to managing conditions like hypertension.
Patient Experiences
Individuals who have discontinued the medication describe a powerful return of cravings.
"I experienced a trigger that goes on and you're instantly ravenous," said one woman.
This difficulty is compounded if individuals have not established lasting lifestyle or habit changes during therapy.
Widespread Adoption
Figures show that a significant number of adults in the UK have used these injections in the past year, with interest being substantial.
- Use is more common among females than men.
- The middle-aged demographic shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
Ultimately, clinicians caution that while these medications are effective agents for shedding pounds, they are not a permanent cure and maintained weight loss relies on ongoing lifestyle support.
